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Particle Size Reduction of Active Pharmaceutical Ingredients (API ). The wet milling technology of WAB allows for effectively reducing the particle size of API and excipients. With the DYNO®-MILL PHARMA equipment, coarse particles are milled to establish the required particle size distribution. The DYNO®-MILL PHARMA equipment line is capable of mechanical Micronization and Nanosization at current Good Manufacturing Practice (cGMP) level protocols. Realised through semi-automatic or fully automatic control units, and the 21 CFR part 11 compliant WAB SCADA-System. In addition, selected DYNO®-MILL PHARMA units are available with Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) functionality. WAB supports its customers with great attention to detail from the initial definition of the User Requirement Specification (URS) throughout the IQ/OQ.


The Pharmaceutical Manufacturer first prepares a pumpable suspension of the solid API in a liquid medium. This raw suspension usually has a very wide particle size distribution and contains a high percentage of coarse particles. The coarse particles are mainly formed by aggregated and agglomerated API material.

The main task of the DYNO®-MILL PHARMA equipment is to disperse the aggregates and agglomerates to the desired particle size distribution.

With the many stages and requirements in the API development process, a broad range of solutions is a helpful support. 

WAB has decades of experience in the Pharmaceutical Industry and a proven spectrum of equipment to supports its global customer base.

DYNO®-MILL PHARMA wet milling equipment:

  • is available in sizes ranging from initial R&D to full scale production
  • allows to process soft milling as well as high energy milling
  • enables particle size distributions from 10 micrometers down to and below 100 nanometers



For the various milling tasks, you need a supplier offering a broad range of products and experience. The combination of these abilities ensures reliable project support and on-time delivery.

Depending on the individual product selection, the DYNO®-MILL PHARMA equipment support offers:

  • WAB qualification concept (FDS, DQ, IQ and OQ)
  • Factory Acceptance Test (FAT)
  • Site Acceptance Test (SAT)
  • Semi-automatic or fully automatic control units
  • 21 CFR part 11 compliant WAB SCADA-System
  • Cleaning-in-Place (CIP)
  • Sterilization-in-Place (SIP)
  • Nanomilling
  • Execution in 316 L or ceramic materials
  • Suitability for temperature sensitive products
  • Suitability for low dust environments
  • Low energy consumption
  • Compact machine sizes
  • Low noise levels
  • Mobile skid units available
  • Fast production changes
  • and more …



Pharmaceutical Industry