Paracetamol synthesis

SOLVENT FREE STRATEGY TO SYNTHESIZE API

In recent years, the production of paracetamol has steadily increased and is expected to continue to grow in the coming years. Thereforex, it is reasonable to research mechanochemical methodologies to produce paracetamol in a more sustainable way.

Higher yield and no need for solvents

Paracetamol is a drug that is used to relieve pain and reduce fever. Compared to the current solvent-based production process, the process on the DYNO-MILL RESEARCH LAB achieves a higher yield and at the same time enables the removal of solvents during the chemical reaction.

Mechanical force

The application of high energy through shear, impact and shock enables a mechanochemical reaction.

Faster reaction

The process time for the synthesis with the DYNO-MILL RESEARCH LAB was 30 minutes compared to 1 hour with a solvent-based process.

Better quality

The yield for this reaction was 89 % compared to 74 % for a solvent-based batch tank reaction.

Scalability

This is the first application of the DYNO-MILL technology for the sustainable mechanochemical synthesis of acetaminophen, known as paracetamol. Comparable studies with conventional ball mills enabled the production of only a few milligrams. However, these small-scale results are not scalable. The optimized solvent-free methodology based on the DYNO-MILL technology delivered a final product on the scale of several centigrams, proving its suitability for industrial scale-up.

Solvent-free reaction

Compared to the current solvent-based production process, the proposed process achieves a higher yield while eliminating the need for solvents in the chemical reaction, thereby reducing one of the main factors for waste generation.

DYNO-MILL RESEARCH LAB

The solution for achieving reactions in flow chemistry with less solvent and lower energy consumption.

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Would you like to find out more? You can find more information in the paper.

 

The research was done by R. Geib and Prof. Dr. L. Gremaud, School of Engineering and Architecture of Fribourg (Switzerland), Department of Chemistry - Institute of Chemical Technology and Prof. Dr. E. Colacino, ICGM, Université Montpellier (France).
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cssc.202301921

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